Route 61 in Pemiscot County will be reduced to one lane as contractor crews resurface the roadway.
The section of roadway is located from Interstate 55 to the Arkansas State Line.
Weather permitting, the work will begin Thursday, and continue through Thursday, July 26, from 6 a.m.-6 p.m. daily.
The work zone will be marked with signs. Motorists are urged to use extreme caution while traveling near the area.
For additional information, call the MoDOT Customer Service Center at 88-ASK-MODOT, or visit www.modot.org/southeast.